{"product_id":"pe-22-28","title":"PE-22-28","description":"\u003cp\u003ePE-22-28 is a synthetic derivative of the naturally occurring protein called spadin. Spadin is a natural peptide derived from sortilin, an abundant protein in the central nervous system. PE-22-28 peptide is one such shortened peptide derivative of this protein; similar to spadin, PE-22-28 research indicates it primarily acts via the TREK-1 receptor. Researchers Djillani et al. commented that PE-22–28 may be “\u003cem\u003ethe shortest, most efficient sequence capable of blocking the TREK-1 channel\u003c\/em\u003e” and may have a potentially higher potency in research settings than spadin.\u003c\/p\u003e\n\u003cp\u003eTREK-1 (TWIK-related potassium channel) receptor is a two-pore potassium channel recently identified as a potential target for studying and modifying animal models of depression. In 2010, research suggested that when TREK-1 receptors were removed from murine models, they became more resistant to depression. TREK-1 receptor is primarily found in the brain region, including the prefrontal cortex and hippocampus, i.e., areas governing mood, memory, and learning. Simulating the TREK-1 receptor may reduce neuron excitability, whereas reducing the receptor activity may increase neuron excitability. While mainly evaluated in the study of depression models, this receptor may also play a strong role in anesthesia, pain perception, and protection of neurons.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImportant Note:\u003c\/strong\u003e\u003cspan\u003e PE-22-28 is intended for research purposes only and should not be used for human consumption or self-administration. Always ensure compliance with local regulations when handling peptides.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Iron Health Peptides","offers":[{"title":"10mg","offer_id":48861277061314,"sku":null,"price":60.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0728\/7518\/0226\/files\/PE-22-28_10mg.png?v=1789689932","url":"https:\/\/ironhealthpeptides.is\/products\/pe-22-28","provider":"Iron Health Peptides","version":"1.0","type":"link"}