PE-22-28

PE-22-28 is a synthetic derivative of the naturally occurring protein called spadin. Spadin is a natural peptide derived from sortilin, an abundant protein in the central nervous system. PE-22-28 peptide is one such shortened peptide derivative of this protein; similar to spadin, PE-22-28 research indicates it primarily acts via the TREK-1 receptor. Researchers Djillani et al. commented that PE-22–28 may be “the shortest, most efficient sequence capable of blocking the TREK-1 channel” and may have a potentially higher potency in research settings than spadin.

TREK-1 (TWIK-related potassium channel) receptor is a two-pore potassium channel recently identified as a potential target for studying and modifying animal models of depression. In 2010, research suggested that when TREK-1 receptors were removed from murine models, they became more resistant to depression. TREK-1 receptor is primarily found in the brain region, including the prefrontal cortex and hippocampus, i.e., areas governing mood, memory, and learning. Simulating the TREK-1 receptor may reduce neuron excitability, whereas reducing the receptor activity may increase neuron excitability. While mainly evaluated in the study of depression models, this receptor may also play a strong role in anesthesia, pain perception, and protection of neurons.

Important Note: PE-22-28 is intended for research purposes only and should not be used for human consumption or self-administration. Always ensure compliance with local regulations when handling peptides.